Switching From Methadone to Tapentadol for Cancer Pain. A Case Report.
Switching From Methadone to Tapentadol for Cancer Pain. A Case Report.
Filed under: Methadone Detox
J Pain Symptom Manage. 2012 Jul 21;
Mercadante S, Ferrera P, Adile C
Prevalence and correlates for nonmedical use of prescription opioids among urban and rural residents.
Filed under: Methadone Detox
Drug Alcohol Depend. 2012 Jul 20;
Wang KH, Becker WC, Fiellin DA
BACKGROUND: In the United States, rural areas have reported an increase in overdose deaths secondary to nonmedical use of prescription opioids. Little is known about the differences in nonmedical use of prescription opioids among urban and rural adults. METHODS: Using the 2008-2009 National Survey on Drug Use and Health, we examined the prevalence of nonmedical use of prescription opioids in urban and rural counties and determined bivariate and multivariate associations, stratified by county. We also compared type of opioids, stratified by county. RESULTS: Among 75,964 respondents, the prevalence of nonmedical use of prescriptions opioids was similar among residents in urban and rural counties (4.7% vs. 4.3%, p=0.15). Urban and rural residents with severe psychological distress and nonmedical use of other prescription medications were more likely to report nonmedical use of opioids. Urban residents whose first use of illicit drugs was between the age of 18 and 25 and who reported alcohol use were more likely to report nonmedical use. Black and Hispanic urban residents were less likely to use prescription opioids nonmedically compared to white urban residents. Rural residents were more likely than urban residents to use acetaminophen with propoxyphene (61.1% vs. 55.8%, p=0.02), methadone (14.8% vs. 9.1%, p=0.003) and acetaminophen with codeine (3.5% vs. 1.9%, p=0.05). CONCLUSIONS: Prevalence and risk factors related to nonmedical use of opioids are similar between urban and rural residents; however rural residents report propoxyphene, codeine, and methadone use more than their urban counterparts. Prevention and treatment interventions may need to be tailored for specific communities.
Source
Quantitative Prediction of CYP2B6 Induction by Estradiol During Pregnancy, Potential Explanation for Increased Methadone Clearance during Pregnancy.
Filed under: Methadone Detox
Drug Metab Dispos. 2012 Jul 19;
Dickmann LJ, Isoherranen N
There is considerable evidence that pregnancy changes the disposition of drugs in an enzyme and gestational stage specific manner. Based on probe drug studies the activity of CYP3A4 and CYP2D6 increases and CYP1A2 decreases during human pregnancy. However, no studies of CYP2B6 activity during human pregnancy have been conducted. In rodent models and in HepG2 cells, CYP2B isoforms have been shown to be regulated by estradiol. As estradiol concentrations increase about 50-fold during human pregnancy, it was hypothesized that the increasing estradiol concentrations during human pregnancy would result in induction of CYP2B6 activity. Hepatocytes from three female donors were treated with estradiol and the EC50 and Emax measured for CYP2B6 mRNA and bupropion hydroxylation activity. The measured values were used to predict the magnitude of CYP2B6 induction during human pregnancy. At 100 nM total estradiol, a concentration achievable during the third trimester of pregnancy, CYP2B6 activity was predicted to increase between 1.5 and 3- fold based on increased CYP2B6 activity and mRNA, respectively. When the E(max) and EC(50) values were compared to carbamazepine and rifampin, estradiol was found to be as potent an inducer of CYP2B6 as rifampin and carbamazepine. These data suggest that during human pregnancy, the increasing estradiol concentrations will result in increased clearance of drugs that have CYP2B6 mediated clearance pathways. This could in part explain the observed increase in methadone clearance during pregnancy.
Source
methadone detox at home intro.wmv – Methadone detox at home introduction to online detox program. Buy “How to methadone detox program on-line” from www.DrugRehabAdvisor.com
Mayor: no detox = no harm reduction
Filed under: Methadone Detox
Abbotsford Mayor Bruce Banman and some members of council have made it clear they aren't interested in changing the city's anti-harm reduction bylaws unless Fraser Health provides more detox services to the community. "If Fraser Health isn't … Under …
Read more on Abbotsford Times
Find More Methadone Detox Information…