Can Heroin-Dependent Individuals Benefit From a Methadone Maintenance Treatment Program Before They Drop Out Against Medical Advice? a 12-Month Follow-Up Study.
Can Heroin-Dependent Individuals Benefit from a Methadone Maintenance Treatment Program before They Drop Out against Medical Advice? A 12-Month Follow-Up Study.
Filed under: Methadone Clinics
Eur Addict Res. 2012 Nov 23; 19(3): 155-164
Wang PW, Wu HC, Lin HC, Yen CN, Yeh YC, Chung KS, Chang HC, Yen CF
Aim: Little is known about whether heroin-dependent individuals receiving methadone maintenance treatment (MMT) who were discharged involuntarily and against medical advice (DAMA) get benefits before they left. The aims of this 12-month follow-up study were to examine whether the effects of MMT on depressive symptoms, heroin dependence and quality of life (QOL) are different among the non-DAMA group, the DAMA group, and the involuntarily discharged group, as well as the time effect of receiving MMT on changes in these three outcome indicators. Method: A total of 266 individuals receiving MMT were divided into the non-DAMA group, the DAMA group, and the involuntarily discharged group. Participants were interviewed at baseline and at 3, 6, 9, and 12 months of treatment for levels of depressive symptoms, heroin dependence and QOL. Results: The levels of depressive symptoms, heroin dependence and QOL in all three groups improved after receiving MMT for 3 months and the improvement was maintained during the MMT period. There were no significant differences in the three outcome indicators among the three groups. Conclusion: The results support the concept that heroin-dependent individuals benefit from MMT, even if they do not want to stay in the program or drop out involuntarily.
HubMed – Methadone
Perioperative changes in cardiac troponin I concentrations in dogs.
Filed under: Methadone Clinics
Res Vet Sci. 2012 Nov 21;
Verbiest T, Binst D, Waelbers T, Coppieters E, Polis I
This study determines the influence of general anesthesia on serum cardiac troponin I (cTnI) concentrations in dogs. All dogs showed no abnormalities on clinical and echocardiographic examination. Venous blood samples were drawn within 12h of induction and 12h after discontinuation of anesthesia. Each dog was premedicated with methadone IV and induced with diazepam IV and propofol IV. Anesthesia was maintained using isoflurane in oxygen in combination with a continuous rate infusion of fentanyl. The cTnI concentrations were measured using a third generation chemiluminescent microparticle immunoassay with a detection limit of 0.01ng/mL (below this level ‘<0.01ng/mL'). Ten dogs (55%) had a post-anesthetic increase of cTnI concentration relative to their pre-anesthetic cTnI concentration, whereas a decrease was observed in two dogs (11%). This study shows that cTnI can increase in healthy dogs undergoing general anesthesia. HubMed – Methadone
Methadone diminishes neuroinflammation and disease severity in EAE through modulating T cell function.
Filed under: Methadone Clinics
J Neuroimmunol. 2012 Nov 20;
Kafami L, Etesami I, Felfeli M, Enayati N, Ghiaghi R, Aminian A, Dehpour A
Methadone is known to exert modulatory effects on the immune system. We investigated the potential effects of methadone on infiltration of inflammatory cells into the spinal cord, as well as the proliferative and cytokine responses of T cells in MOG(35-55)-induced experimental autoimmune encephalomyelitis in mice. Methadone significantly suppressed clinical signs of the disease and level of inflammatory cytokines (p<0.05) produced by T cells. Moreover, invasion of inflammatory cells into the spinal cord was significantly decreased by methadone (p<0.05). Our data point to therapeutic effects of methadone and highlight the beneficial role of opioid receptor signaling in the context of autoimmune neuroinflammation. HubMed – Methadone
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