[Rate of retention and related factors on patients under methadone maintenance treatment in Beijing: a prospective cohort study].

Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Dec; 33(12): 1248-51
Liu GW, Wang J, Lu HY

To study the rates of retention and associated factors on patients under methadone maintenance treatment (MMT) in Beijing.A prospective cohort was conducted among 548 patients who enrolled in MMT clinics during 2004 – 2006 in Beijing. Log-rank method and Cox PH regression models were used to study related factors associated with long-term retention.Of the 548 patients, 463 (79.6%) were males, with 515 (94.0%) under Han ethnicity. 443 (80.8%) of them were unemployed with 449 (81.9%) as injecting drug users at the time of enrollment. The average age and duration of drug abuse at enrollment were 37.3 ± 6.7 and 9.1 ± 4.0 years, respectively. The median length of treatment was 2.1 years with five-year retention rate as 41.2%. The long-term retention rates between different dosages (Log-rank ?(2) = 10.527, P = 0.005), treatment ratio (Log-rank ?(2) = 19.027, P < 0.001) and illicit drug use (Log-rank ?(2) = 159.485, P < 0.001) showed significant differences, statistically. Factors as having high education level (HR = 0.76, P = 0.021), with daily dosage 60 mg/day or more (HR = 0.64, P = 0.002), having 1% - 9% times urine morphine positive result (HR = 0.32, P < 0.001) seemed to be able to predict the lower risk of dropout during the follow-up period. However, frequent illicit drug use (> 20%) (HR = 2.92, P < 0.001) could increase the risk of dropout.Treatment with higher dosage (? 60 mg/day) of methadone seemed to have decreased the possibility of dropout during the follow-up period, whereas frequent illicit drug use (? 20%) was important risk factor causing long-term retention. HubMed – Methadone

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