Effect of Hepatitis C Virus Status on Liver Enzymes in Opioid-Dependent Pregnant Women Maintained on Opioid-Agonist Medication.
Effect of hepatitis C virus status on liver enzymes in opioid-dependent pregnant women maintained on opioid-agonist medication.
Filed under: Methadone Treatment
Addiction. 2012 Nov; 107 Suppl 1: 91-7
McNicholas LF, Holbrook AM, O’Grady KE, Jones HE, Coyle MG, Martin PR, Heil SH, Stine SM, Kaltenbach K
To examine hepatic enzyme test results throughout the course of pregnancy in women maintained on methadone or buprenorphine.Participants were randomized to either methadone or buprenorphine maintenance. Blood chemistry tests, including liver transaminases and hepatitis C virus (HCV) status, were determined every 4 weeks and once postpartum. As part of a planned secondary analysis, generalized mixed linear models were conducted with aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) as the dependent variables.Six US sites and one European site that provided comprehensive treatment to pregnant opioid-dependent women.A total of 175 opioid-dependent pregnant women enrolled in the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study.ALT, AST and GGT levels decreased for all subjects across pregnancy trimesters, rising slightly postpartum. HCV-positive subjects exhibited higher transaminases at all time-points compared to HCV-negative subjects, regardless of medication (all Ps?Source
Infections and obstetric outcomes in opioid-dependent pregnant women maintained on methadone or buprenorphine.
Filed under: Methadone Treatment
Addiction. 2012 Nov; 107 Suppl 1: 83-90
Holbrook AM, Baxter JK, Jones HE, Heil SH, Coyle MG, Martin PR, Stine SM, Kaltenbach K
To characterize infections and compare obstetric outcomes in opioid-dependent pregnant women who participated in a randomized clinical trial comparing agonist medications, methadone and buprenorphine.Incidence of infections was identified as part of the screening medical assessment. As part of a planned secondary analysis, analysis of variance and polytomous logistic regressions were conducted on obstetric outcome variables using treatment randomization condition (maternal maintenance with either methadone or buprenorphine) as the predictor variable, controlling for differences between study sites.Six United States sites and one European site that provided comprehensive treatment to opioid-dependent pregnant women.Pregnant opioid-dependent women (n?=?131) who delivered while participating in the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study.Obstetric, infectious and other maternal medical complications captured by medical records, physical examination, blood tests and self-report. Neonatal medical complications captured by medical records.Hepatitis C was the most common infection (32.3%), followed by hepatitis B (7.6%) and chlamydia (6.1%) among participants at study enrollment. Maternal methadone versus buprenorphine maintenance was associated with a higher incidence of preterm labor (P?=?0.04) and a significantly higher percentage of signs of respiratory distress in neonates at delivery (P?=?0.05). Other medical and obstetric complications were infrequent in the total sample, as well as in both methadone and buprenorphine conditions.Buprenorphine appears to have an acceptable safety profile for use during pregnancy.
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Neonatal neurobehavior effects following buprenorphine versus methadone exposure.
Filed under: Methadone Treatment
Addiction. 2012 Nov; 107 Suppl 1: 63-73
Coyle MG, Salisbury AL, Lester BM, Jones HE, Lin H, Graf-Rohrmeister K, Fischer G
To determine the effects of in utero exposure to methadone or buprenorphine on infant neurobehavior.Three sites from the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a double-blind, double-dummy, randomized clinical trial participated in this substudy.Medical Centers that provided comprehensive maternal care to opioid-dependent pregnant women in Baltimore, MD, Providence, RI and Vienna, Austria.Thirty-nine full-term infants.The Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale (NNNS) was administered to a subgroup of infants on postpartum days 3, 5, 7, 10, 14-15 and 28-30.While neurobehavior improved for both medication conditions over time, infants exposed in utero to buprenorphine exhibited fewer stress-abstinence signs (P?Source
Methadone found in car involved in fatal crash
Filed under: Methadone Treatment
Methadone prescribed through treatment clinics is meant to be drunk, not injected, methadone treatment professionals say. The two county workers killed were Zachary M. Gamache, 25, of Esko and Mitchell D. Lingren, 29, of Duluth. According to the State …
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