[Effects of Methadone Maintenance Treatment on Working Memory in Male Heroin Dependent Patients].
[Effects of methadone maintenance treatment on working memory in male heroin dependent patients].
Filed under: Methadone Side Effects
Zhonghua Yi Xue Za Zhi. 2012 Feb 21; 92(7): 464-7
Yin LS, Li ZA, Pang LJ, Zhu CY, Wang SM, Zhang L, Tang WC, Dai J
To explore the differences of working memory task performance between male patients with heroin dependence in methadone maintenance treatment (MMT) and healthy controls (HC).A total of 42 heroin-dependent patients at Huainan City Psychiatric Hospital from May 2011 to October 2011 were compared with 31 gender- and age-matched HCs on such working memory tests as visual-space, visual-verbal and visual-face. Then the accurate rate and reaction time of the above tasks were between two groups.The participants with anxiety or depression were excluded. All MMT subjects were required to have negative urine toxicology screening tests. The accurate rate of verbal working memory of the patients was worse than that of HCs (83% ± 9% vs 89% ± 10%). And the difference was significant between two groups (t(71) = -2.631, P = 0.010). The accurate rate of visual-object and visual-spatial working memory showed no significant differences between two groups (P > 0.05). The differences in reaction time on these tasks showed no statistical significance between two groups (P > 0.05). In addition, the dose of methadone and the duration of MMT revealed no significant effects on the performance of working memory and executive functions.The disproportion impairment of patients on space, verbal and face working memory is probably due to the differential heroin-mediated injuries of encephalic regions. Methadone has no effect on working memory and executive functions in the patients with a history of heroin use during maintenance treatment intervention.
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How to understand Mixing Methadone with other medications with Dr Rodriquez and Delray Center – Mixing Methadone with other medications “Lets talk about mixing Methadone with other medications its rather common in modern medicine for a patient to take more then one medicine. That holds true for people on Methadone as well. Now Methadone can be taken safely with most antidepressants. Although some antidepressants do have interactions with Methadone that have to be accounted for. Fluoxetine or prozac is notable in that it interacts with Methadone and will tend to prolong the half-life of Methadone. This results in the Methadone dosage having to be adjusted often times may lower for safety reason. Other medications also have significant interactions with Methadone that are more concerning. Medications from the benzodiazepine family such as xanax klonopin and Valium do mix with Methadone and the actual mix can have a very powerful effect on the human body. This affect can be dangerous and can lead into an accidental overdose if not accounted for carefully with they dosage. Usually when medications are mixed and both medications are controlled substances with direct interactions that can affect a person’s ability to hold their heartbeat and there regular breathing dosage adjustments have to be made. These adjustments are done by a licensed and qualified physicians and should never be done by any patient on their own at home. If somebody is ever having doubts as far as medications that they are taking at the same time with Methadone they should contact their physician or …
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